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Ubiquitin & Proteasome: How Cells Destroy Damaged Proteins
Every second, your cells are performing a high-stakes balancing act. While we often focus on how the body builds proteins, what happens when those proteins break down or get tangled? In this video, we dive deep into the fascinating world of the proteasome—the cell’s ultimate quality-control machinery. We explore the "tagging" system known ...
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Brianna Bibel on Instagram: "Targeted protein degradation (via PROTACs, molecular glues, conditional degron tags etc.) https://youtube.com/shorts/vr_FeRVypfE Our bodies use the Ubiquitin-Proteasome System (UPS) to target unwanted proteins (via the addition of chains of a small protein called ubiquitin) to the proteasome (protein-shredder). Much more on the UPS and how it works “normal-function-wise” in a past post I will link to. But today I want to talk about how we can hijack this system to se
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