A protein’s three-dimensional (3D) structure, physicochemical properties and molecular function are defined by its amino-acid sequence. From the 20 commonly occurring proteinogenic amino acids, a ...
SSEmb: A joint embedding of protein sequence and structure enables robust variant effect predictions
The ability to predict how amino acid changes affect proteins has a wide range of applications including in disease variant classification and protein engineering. Many existing methods focus on ...
The expression pattern of a single gene or multiple genes can be investigated using a technique RNA microarray. In this technique, RNA molecules are ‘spotted’ onto a solid surface. These act as probes ...
AI protein function prediction is reshaping how laboratories approach protein annotation, hypothesis generation, and translational research. As sequencing technologies continue to outpace experimental ...
Evolutionary biologists like us try to figure out how organisms – from Tyrannosaurus Rex to influenza – evolve. For more than 100 years, scientists have thought about evolution through a framework ...
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