Calcium (Ca²⁺) signalling is essential for cardiomyocyte function, regulating excitation–contraction coupling and excitation–transcription coupling, and contributing to mitochondrial energy production ...
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) lack nanoscale structures essential for efficient excitation–contraction coupling. Such nanostructures, known as dyads, are ...
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
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