A large share of medicines developed today may never reach patients for a surprisingly simple reason: they cannot dissolve well enough in water. For most treatments, the oral route remains the gold ...

Poor aqueous solubility of medicines has been a subject of great interest for improvement of pharmaceutical industry. Computational analysis of solubility data is of great importance for evaluation of ...

Traditionally, pharmaceutical particle production processes use several organic solvents for processing their products. Quite often, remnant of solvents causes serious pollution and sometimes ...

About 40% of marketed drugs are thought to be poorly water soluble. Development efforts might have to be redoubled, however, because between 70 and 90% of drug candidates in the pipeline are believed ...

These plots show powder X-ray diffraction measurements of three different types of formulations: simple mixing (a, d), the conventional evaporation/condensation ...

What is the process of oral drug absorption, and how has the Fa equation evolved? Oral drug absorption begins with administering a drug product, followed by a rapid disintegration process. The drug ...

The anti-anxiety drug diazepam causes side effects: drowsiness, confusion, and nausea. The same applies to the antidepressant amitriptyline. A possible solution to the problem could be a new compound, ...

Only about 4% of candidate drugs reach the market. The main culprits of this failure are due to issues with dosing , exposure and toxicity. Join us as Dr. Paul Leeson shares how improving candidate ...

Formulation complexity, especially in small molecule drugs, has been getting more attention as capabilities continue to ...

Bend Research Inc. (), a leading independent drug-formulation development and manufacturing company, announced that it has received two new U.S. patents related to its pioneering efforts to improve ...

Over 141,000 bottles of cholesterol medication have been recalled due to “failed dissolution specifications,” suggesting that ...